The actin and intermediate filament cytoskeletons contribute to numerous cellular processes,
The actin and intermediate filament cytoskeletons contribute to numerous cellular processes, including morphogenesis, migration and cytokinesis. known BSF 208075 as ARHGEF2). Vimentin depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA CSF1R activity and actin stress fiber assembly. Taken together, these data reveal a new mechanism by which intermediate filaments regulate … [Read more…]