Background The autoimmune disease systemic lupus erythematosus (SLE) has a modified
Background The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 to H3K36me3, a transcriptional elongation mark, is often found. The Acitazanolast H3K4me3 pattern was strongly associated with transcription in SLE. Genes with narrow peaks were less likely … [Read more…]