CD45 is a receptor-like tyrosine phosphatase that positively regulates BCR signaling
CD45 is a receptor-like tyrosine phosphatase that positively regulates BCR signaling by dephosphorylating the inhibitory tyrosine of the Src family kinases (SFKs). demonstrates that relaxing negative regulation of BCR signaling rather than enhancing positive regulation is critical for driving autoimmunity in this system. mice were generated directly on the C57BL/6 genetic background during N-ethyl-N-nitrosourea mutagenesis … [Read more…]