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Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely

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Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely recognized pathophysiologic feature of sepsis-induced severe kidney injury (AKI), the molecular mechanisms in charge of this phenomenon are unidentified. Immunoblot analysis uncovered activation of tumor development locus 2/mitogen-activated proteins kinase kinase/extracellular signal-regulated kinase (TPL-2/MEK/ERK) signaling in the renal cortex by LPS. Pharmacologic inhibition of … [Read more…]

The potency of adult-derived circulating progenitor endothelial colony forming cells (ECFCs)

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The potency of adult-derived circulating progenitor endothelial colony forming cells (ECFCs) is drastically surpassed by their fetal counterparts. square endothelium, constituting 12.5% of maternal vessel lumina. Cross-sections of comparable human vessels, hybridized for Y-chromosome, positively recognized endothelial-associated fetal cells. It appears that through ECFC donation, fetuses aid maternal uterine vascular growth in pregnancy, potentiating placental … [Read more…]