Mitochondrial dysfunction and oxidative stress are recognized to occur subsequent severe
Mitochondrial dysfunction and oxidative stress are recognized to occur subsequent severe seizure activity but their contribution during epileptogenesis is basically unknown. pursuing lithium-pilocarpine administration. A time-dependent upsurge in mitochondrial hydrogen peroxide (H2O2) creation coincident with an increase of mtDNA lesion rate of recurrence in the hippocampus was noticed during epileptogenesis. Acute raises (24-48 h) in … [Read more…]