SAHA – Targeting the ubiquitin–proteasome system for cancer therapy

The class I p21-activated kinases (Pak1-3) regulate many essential biological processes

August 16, 2017 by Katherine Lewis Leave a Comment

The class I p21-activated kinases (Pak1-3) regulate many essential biological processes including cytoskeletal rearrangement cell cycle progression apoptosis and cellular transformation. A characteristic that distinguishes the atypical MAPKs from the classical MAPK isoforms is the lack of the characteristic “T(16). However a cell fractionation approach to identify the kinases responsible for Erk3 Ser189 phosphorylation suggested … [Read more…]

Background Glycerol monolaurate (GML) can be an antimicrobial agent which has

June 25, 2017 by Katherine Lewis Leave a Comment

Background Glycerol monolaurate (GML) can be an antimicrobial agent which has potent activity against gram-positive bacteria. and in broth civilizations. Both substances inhibit superantigen creation by these microorganisms at concentrations that aren’t bactericidal. GML prevents biofilm development by and and and on sub-growth inhibitory concentrations of GML (0.5 x minimum bactericidal concentration) resistance to GML … [Read more…]