SB-207499

SRPK2 belongs to a family of serine/arginine (SR) protein-specific kinases (SRPKs)

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SRPK2 belongs to a family of serine/arginine (SR) protein-specific kinases (SRPKs) which phosphorylate SR domain-containing proteins in the nuclear speckles and mediate the pre-mRNA splicing. cells. SR proteins and the related proteins are generally believed to modulate splice site selection via RNA recognition motif (RRM)-mediated binding to exonic splicing enhancers and SR domain-mediated protein-protein and … [Read more…]

Vascular development is dependent on various growth factors and certain modifiers

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Vascular development is dependent on various growth factors and certain modifiers critical for providing arterial or venous identity interaction with the surrounding stroma and tissues hierarchic network formation and recruitment of pericytes. perfusion. sDll4 similarly induced defective vascular response in tumor implants leading to reduced tumor growth. Interference with Dll4-Notch signaling may be particularly desirable … [Read more…]