The current paradigm states that exit from mitosis is triggered by
The current paradigm states that exit from mitosis is triggered by the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) acting in concert with an activator called CDC20. 1 (CDK1)-inhibitory phosphorylation was activated during mitotic departure in CDC20-exhausted cells. The phrase of an siRNA-resistant CDC20 rescued both the mitotic departure hold off and the CDK1-inhibitory phosphorylation. Furthermore, the … [Read more…]