Mutations of tumor suppressor gene deregulate Ras-mediated signaling, which confers the
Mutations of tumor suppressor gene deregulate Ras-mediated signaling, which confers the predisposition for developing benign or malignant tumors. abnormality of which causes the development of peripheral nerve tumors consisting 60C85% Schwann cells and 10C20% fibroblasts with small amounts of pericytes, perineurial cells, mast cells, endothelial and easy muscle mass cells.12-15 Some of NF1 patients develop … [Read more…]