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Targeting the ubiquitin–proteasome system for cancer therapy

URB754

E3 ubiquitin ligases are fundamental enzymes inside the ubiquitin proteasome program

March 11, 2019 by Katherine Lewis Leave a Comment

E3 ubiquitin ligases are fundamental enzymes inside the ubiquitin proteasome program which catalyze the ubiquitination of protein, targeting them for proteasomal degradation. ubiquitin near one another to catalyze the transfer of the ubiquitin molecule towards the substrate4, 5. Substrate ubiquitination can cause different cellular final results6, which one of the better characterized is normally poly-ubiquitination … [Read more…]

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