R406 – Targeting the ubiquitin–proteasome system for cancer therapy

Level of resistance to platinum-based chemotherapy may be the main hurdle

February 27, 2019 by Katherine Lewis Leave a Comment

Level of resistance to platinum-based chemotherapy may be the main hurdle to treating epithelial ovarian tumor. the Wnt/-catenin particular inhibitor iCG-001 potently sensitized cells to cisplatin and reduced stem-cell regularity in platinum resistant cells. Used jointly, our data may be the first record providing evidence the fact that Wnt/-catenin signaling pathway maintains stem-like properties and … [Read more…]

Acquisition of the pluripotent condition coincides with epigenetic reprogramming from the

June 19, 2017 by Katherine Lewis Leave a Comment

Acquisition of the pluripotent condition coincides with epigenetic reprogramming from the X-chromosome. by low degrees of the noncoding Xist RNA as well as the lack of heterochromatin marks over the X-chromosome. Individual pluripotent stem cells nevertheless display X-chromosome epigenetic instability that may possess implications because of their make use of in regenerative medication. XIST heterochromatin … [Read more…]